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Chronic sequelae and irreversible injuries following acute pyrethroid intoxication.
Toxicology Letters 105 (1999) 161-175.
Mueller-Monhssen H
Physiological Institute, Ludwig Maximilians University, Munich, Germany.
For patients the author has observed, the majority of complaints following an acute pyrethroid intoxication disappeared after the end of exposure. Residuals frequently observed after more than 2 years were: (1) cerebro-organic disorders (reduced intellectual performance with 20-30% reduction of endurance during mental work, personality disorder), visual disturbances, dysacousia, tinnitus; (2) sensomotor-polyneuropathy most frequently in the lower legs; (3) vegetative nervous disorders (paroxysma tachycardia, pollakiuria, increased heat-sensitivity, orthostatic hypotonia and reduced exercise tolerance due to circulatory disorder). Non-neurological symptoms include deficiency of cellular and humoral immune system established by laboratory findings: opportunistic infections, especially Candida-infections of the gastro-intestinal tract, relapsing infections of the urinary and respiratory tract, the latter often aggravating to respiratory obstruction. Most of the patients exhibit positive epi- or intracutaneous test against pyrethroids or pyrethrines, and acquainted sensitivity also to other antigens. Many of these patients exhibit pathological autoimmune diagnostical findings and developed autoimmune diseases as for instance sclerodermia-like syndrome, myasthenia-like syndrome with progredient muscle atrophy, autoimmun-hemolysis and autoimmun-thrombocytopenic purpura.

Lipid peroxidative damage on pyrethroid exposure and alterations in antioxidant status in rat erythrocytes: a possible involvement of reactive oxygen species (pdf 161 Ko)
Toxicology Letters 105 (1999) 197–205
M. Kale, N. Rathore, S. John, D. Bhatnagar
School of Biochemistry, D.A. University, Khandwa Road, Indore 452 017, India

Lymphocyte DNA damage in rats exposed to pyrethroids : effect of supplementation with Vitamins E and C (pdf 105 Ko)
Toxicology 203 (2004) 17–26
Rosita Gabbianelli, Cinzia Nasuti, Giancarlo Falcioni, Franco Cantalamessa
Dipartimento di Scienze Farmacologiche e Medicina Sperimentale & Dipartimento di Biologia M.C.A. Biology, Università di Camerino, Via Camerini 2, Camerini (MC) 62032, Italy

Genotoxicity of pesticides : a review of human biomonitoring studies (pdf 181 Ko)
Mutation Research 543 (2003) 251–272
Claudia Bolognesi
Toxicological Evaluation Unit, National Cancer Research Institute—Largo Rosanna Benzi 10, 16132 Genova, Italy




Révision : 07 décembre 2004 .
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