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Pyréthroïdes
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Chronic
sequelae and irreversible injuries following acute pyrethroid
intoxication.
Toxicology Letters 105 (1999) 161-175.
Mueller-Monhssen H
Physiological Institute, Ludwig Maximilians University, Munich,
Germany.
For patients the author has observed, the majority of complaints
following an acute pyrethroid intoxication disappeared after the end of
exposure. Residuals frequently observed after more than 2 years were: (1) cerebro-organic
disorders (reduced intellectual performance with 20-30% reduction
of endurance during mental work, personality disorder), visual
disturbances, dysacousia, tinnitus; (2) sensomotor-polyneuropathy
most frequently in the lower legs; (3) vegetative nervous disorders
(paroxysma tachycardia, pollakiuria, increased heat-sensitivity,
orthostatic hypotonia and reduced exercise tolerance due to circulatory
disorder). Non-neurological symptoms include deficiency of cellular and
humoral immune system established by laboratory findings: opportunistic
infections, especially Candida-infections of the gastro-intestinal
tract, relapsing infections of the urinary and respiratory tract,
the latter often aggravating to respiratory obstruction. Most of the
patients exhibit positive epi- or intracutaneous test against
pyrethroids or pyrethrines, and acquainted sensitivity also to other
antigens. Many of these patients exhibit pathological autoimmune
diagnostical findings and developed autoimmune diseases as for
instance sclerodermia-like syndrome, myasthenia-like syndrome
with progredient muscle atrophy, autoimmun-hemolysis and autoimmun-thrombocytopenic
purpura.
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Lipid peroxidative damage on pyrethroid exposure and alterations
in antioxidant status in rat erythrocytes: a possible involvement
of reactive oxygen species (pdf 161 Ko)
Toxicology Letters 105 (1999) 197–205
M. Kale, N. Rathore, S. John, D. Bhatnagar
School of Biochemistry, D.A. University,
Khandwa Road, Indore 452 017, India
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Lymphocyte DNA damage in rats exposed to pyrethroids : effect
of supplementation with Vitamins E and C (pdf 105
Ko)
Toxicology 203 (2004) 17–26
Rosita Gabbianelli, Cinzia Nasuti, Giancarlo Falcioni, Franco
Cantalamessa
Dipartimento di Scienze Farmacologiche e Medicina
Sperimentale & Dipartimento di Biologia M.C.A. Biology, Università di
Camerino, Via Camerini 2, Camerini (MC) 62032, Italy
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Genotoxicity
of pesticides : a review of human biomonitoring studies
(pdf 181 Ko)
Mutation Research 543 (2003) 251–272
Claudia Bolognesi
Toxicological Evaluation Unit, National Cancer Research
Institute—Largo Rosanna Benzi 10, 16132 Genova, Italy
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Organo-phosphorés
Révision : 07 décembre 2004
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